Role of oxygen radicals and neutrophils in hemorrhagic shock-induced gastric mucosal injury

Thesis/Dissertation · Thu Jan 01 00:00:00 EST 1987

OSTI ID:7138262

Smith, S M

The role of oxygen radicals and neutrophils was examined in ischemia-reperfusion injury to the gastric mucosa in male Sprague-Dawley rats. Gastric mucosal clearance of /sup 51/Cr-labelled red blood cells was measured during a 30 minute control period, 30 minute ischemic period, and a 60 minute reperfusion period. In untreated rats, a dramatic rise in the leakage of /sup 51/Cr-labeled red blood cells into the gastric lumen was observed only during the reperfusion period. Ischemia-reperfusion was also associated with the formation of both grossly visible and histologically demonstrable mucosal lesions. Pretreatment with dimethylsulfoxide or deferoxamine largely prevented gastric bleeding and gross lesion formation, indicating that the hydroxyl radical, generated by the iron-catalyzed Haber-Weiss reaction, is the primary cytotoxic oxygen species involved in ischemia-reperfusion injury.

• Research Organization: University of South Alabama, Mobile (USA)
• OSTI ID: 7138262
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
DIGESTIVE SYSTEM
HEMORRHAGE
HYDROXYL RADICALS
TOXICITY
MUCOUS MEMBRANES
PATHOLOGICAL CHANGES
NEUTROPHILS
BIOLOGICAL FUNCTIONS
CHROMIUM 51
CLEARANCE
DMSO
ERYTHROCYTES
RATS
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM ISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
MAMMALS
MATERIALS
MEMBRANES
NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADICALS
RADIOISOTOPES
RODENTS
SULFOXIDES
SYMPTOMS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550901 - Pathology- Tracer Techniques