Role of oxygen radicals and neutrophils in hemorrhagic shock-induced gastric mucosal injury

Thesis/Dissertation · Wed Dec 31 23:00:00 EST 1986

OSTI ID:7138262

Smith, S M

The role of oxygen radicals and neutrophils was examined in ischemia-reperfusion injury to the gastric mucosa in male Sprague-Dawley rats. Gastric mucosal clearance of /sup 51/Cr-labelled red blood cells was measured during a 30 minute control period, 30 minute ischemic period, and a 60 minute reperfusion period. In untreated rats, a dramatic rise in the leakage of /sup 51/Cr-labeled red blood cells into the gastric lumen was observed only during the reperfusion period. Ischemia-reperfusion was also associated with the formation of both grossly visible and histologically demonstrable mucosal lesions. Pretreatment with dimethylsulfoxide or deferoxamine largely prevented gastric bleeding and gross lesion formation, indicating that the hydroxyl radical, generated by the iron-catalyzed Haber-Weiss reaction, is the primary cytotoxic oxygen species involved in ischemia-reperfusion injury.

• Research Organization: University of South Alabama, Mobile (USA)
• OSTI ID: 7138262
• Country of Publication: United States
• Language: English

Related Subjects

550901 -- Pathology-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
CLEARANCE
DIGESTIVE SYSTEM
DMSO
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
FUNCTIONS
HEMORRHAGE
HYDROXYL RADICALS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
MAMMALS
MATERIALS
MEMBRANES
MUCOUS MEMBRANES
NEUTROPHILS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PATHOLOGICAL CHANGES
RADICALS
RADIOISOTOPES
RATS
RODENTS
SULFOXIDES
SYMPTOMS
TOXICITY
TRACER TECHNIQUES
VERTEBRATES