Childhood familial pheochromocytoma. Conflicting results of localization techniques

Journal Article · Wed Oct 01 04:00:00 EDT 1986 · Hypertension (Dallas); (United States)

DOI:https://doi.org/10.1161/01.HYP.8.10.851· OSTI ID:7134413

Turner, M C; DeQuattro, V; Falk, R; Ansari, A; Lieberman, E

Childhood familial pheochromocytoma was investigated in four patients by abdominal computed tomographic scan, (/sup 131/I)metaiodobenzylguanidine scan, and vena caval catecholamine sampling. Results conflicted with surgical findings. Computed tomographic scan identified all four adrenal tumors but missed two midline tumors in one patient. (/sup 131/I)metaiodobenzylguanidine scan identified two of three adrenal tumors but also suggested extra-adrenal tumors not confirmed at operation in two of three patients. Vena caval sampling for catecholamines confirmed all adrenal tumors but suggested additional tumors not verified at operation in two of three patients. All patients are asymptomatic and have normal urinary catecholamines 15 to 51 months after operation. Because of the frequency of multiple tumors in familial pheochromocytoma, different diagnostic techniques were employed. False-positive results were more frequent with (/sup 131/I)metaiodobenzylguanidine and vena caval sampling. Reinterpretation of the (/sup 131/I)metaiodobenzylguanidine scans at a later date led to less false-positive interpretation, although the false-negative rate remained unchanged. More pediatric experience with (/sup 131/I)metaiodobenzylguanidine scans and vena caval sampling in familial pheochromocytoma is needed. Confirmation of tumor and its localization rest with meticulous surgical exploration.

• Research Organization: Childrens Hospital of Los Angeles, CA
• OSTI ID: 7134413
• Journal Information: Hypertension (Dallas); (United States), Journal Name: Hypertension (Dallas); (United States) Vol. 10; ISSN HPRTD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABDOMEN
ADRENAL GLANDS
AGE GROUPS
AMINES
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
CATECHOLAMINES
CHILDREN
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ENDOCRINE GLANDS
GLANDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PHENOLS
POLYPHENOLS
RADIOISOTOPES
TOMOGRAPHY