Statistical lung model for microdosimetry

Conference · Thu Mar 01 04:00:00 EST 1984

OSTI ID:7132932

Fisher, D R; Hadley, R T

To calculate the microdosimetry of plutonium in the lung, a mathematical description is needed of lung tissue microstructure that defines source-site parameters. Beagle lungs were expanded using a glutaraldehyde fixative at 30 cm water pressure. Tissue specimens, five microns thick, were stained with hematoxylin and eosin then studied using an image analyzer. Measurements were made along horizontal lines through the magnified tissue image. The distribution of air space and tissue chord lengths and locations of epithelial cell nuclei were recorded from about 10,000 line scans. The distribution parameters constituted a model of lung microstructure for predicting the paths of random alpha particle tracks in the lung and the probability of traversing biologically sensitive sites. This lung model may be used in conjunction with established deposition and retention models for determining the microdosimetry in the pulmonary lung for a wide variety of inhaled radioactive materials.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 7132932
• Report Number(s): PNL-SA-12101; CONF-8403115-2; ON: DE84010703
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDES
ANIMALS
BEAGLES
BIOLOGICAL MODELS
BODY
DISTRIBUTION
DOGS
DOSIMETRY
ELEMENTS
LUNGS
MAMMALS
MATHEMATICAL MODELS
METALS
ORGANS
PLUTONIUM
RESPIRATORY SYSTEM
TISSUE DISTRIBUTION
TRANSURANIUM ELEMENTS
VERTEBRATES