Regional brain hematocrit in stroke by single photon emission computed tomography imaging

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Am. J. Physiol. Imag.; (United States)

OSTI ID:7125920

Loutfi, I; Frackowiak, R S; Myers, M J; Lavender, J P

Nineteen studies on 18 subjects were performed by single photon emission computed tomography (SPECT) of the head after the successive intravenous administration of a plasma label (/sup 99m/Tc-human serum albumin (HSA)) and /sup 99m/Tc-labeled autologous red blood cells (RBC). Two sets of cerebral tomographic sections were generated: for cerebral /sup 99m/Tc-HSA alone and for combined /sup 99m/Tc-HSA and /sup 99m/Tc-RBC. By relating counts in regions of interest from the cerebral tomograms to counts from blood samples obtained during each tomographic acquisition, regional cerebral haematocrit (Hct) was calculated by the application of a simple formula. Results show 1) lower cerebral Hct than venous Hct (ratio of HCT brain/Hct venous 0.65-0.90) in all subjects, and 2) comparison between right and left hemisphere Hct in 3/3 normal subjects, 6/6 patients with transient ischaemic attacks and 3/8 patients with stroke showed no significant difference. However, in 3/8 patients with stroke (most recent strokes) significant differences were found, the higher Hct value corresponding to the affected side.

• Research Organization: Atomic Energy Commission of Syria, Damascus
• OSTI ID: 7125920
• Journal Information: Am. J. Physiol. Imag.; (United States), Vol. 2:1
• Country of Publication: United States
• Language: English

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