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Assessment of cardiopulmonary alterations in endotoxic shock

Journal Article · · Am. J. Physiol. Imag.; (United States)
OSTI ID:7125742
; ; ;
Using radionuclide first-pass technique, seven sheep were studied prior to and during endotoxic shock. In vitro labeled /sup 99m/TC red blood cells were used to measure right and left ventricular ejection fractions (RVEF and LVEF) and cardiopulmonary transit time (CPTT) prior to and at 1, 4, 30, and 60 minutes after the intravenous injection of endotoxin Escherichia coli, 3 mg/kg bodyweight. The LVEF decreased slightly from 51 to 42% but became normal four minutes later, while the RVEF remained decreased from 49 to 26% for 60 minutes. The CPTT was prolonged from 13 to 26 cardiac beats. The decrease in RVEF was well correlated with the prolongation of the CPTT.
Research Organization:
Kuwait Univ., Safat
OSTI ID:
7125742
Journal Information:
Am. J. Physiol. Imag.; (United States), Journal Name: Am. J. Physiol. Imag.; (United States) Vol. 1:4; ISSN AJPIE
Country of Publication:
United States
Language:
English

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Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTIGENS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL SHOCK
BLOOD
BLOOD CELLS
BODY FLUIDS
CARDIOVASCULAR SYSTEM
DISEASES
DOMESTIC ANIMALS
ENDOTOXINS
ERYTHROCYTES
ESCHERICHIA COLI
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
PATHOGENESIS
PATHOLOGICAL CHANGES
RADIOISOTOPES
RESPIRATORY SYSTEM
RUMINANTS
SHEEP
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOXIC MATERIALS
TOXINS
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES