Air-pollution effects on nasal function. Final report, June 1986-June 1987
The investigators performed a series of studies to determine whether sulfur dioxide or ozone increase nasal symptoms, nasal resistance to airflow, or nasal responses to other stimuli. In the first study, it was found that sulfur dioxide did not acutely increase nasal symptoms or resistance to airflow in 12 subjects with demonstrated nasal responsiveness to instillation of antigen, or in 10 subjects with a history of nasal responsiveness to antigenic or nonantigenic stimuli. In a second study, it was found that ozone tended to cause an increase in rhinorrhea, nasal congestion and sneezing. However, this increase in symptoms was not statistically significant, was small when compared to the effects of intranasal antigen, and was not associated with a statistically significant, increase in nasal resistance. Biochemical and cellular analysis of nasal lavage fluid from 8 of these subjects did not show a consistent or striking ozone-induced change in histamine, protein, or inflammatory cells in nasal secretions. Finally, results from the third study suggest that ozone augments nasal responsiveness to antigen in at least some subjects with allergic rhinitis.
- Research Organization:
- California Univ., San Francisco (USA). Cardiovascular Research Inst.
- OSTI ID:
- 7125442
- Report Number(s):
- PB-88-215629/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
NOSE
INFLAMMATION
OZONE
BIOLOGICAL EFFECTS
RESPIRATORY SYSTEM DISEASES
SULFUR DIOXIDE
AIR POLLUTION
PROGRESS REPORT
BODY
BODY AREAS
CHALCOGENIDES
DISEASES
DOCUMENT TYPES
FACE
HEAD
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
POLLUTION
RESPIRATORY SYSTEM
SULFUR COMPOUNDS
SULFUR OXIDES
SYMPTOMS
560300* - Chemicals Metabolism & Toxicology
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)