Diagnosis of Barrett's esophagus by pertechnetate radionuclide
In Barrett's esophagus the normal stratified squamous epithelium of esophagus is replaced by columnar epithelium and other characteristics of gastric mucosa. Barrett's esophagus has an increased tendency to bleed and is more prone to undergo malignant change. There are many procedures used to diagnose this entity, but only by serial and multiple esophageal mucosal biopsies can the diagnosis be confirmed. Harper et al. (8) demonstrated an early and intense uptake of 99m Tc pertechnetate by the stomach in animals. Since the Barrett's esophagus is lined by gastric mucosa, pertechnetate scintigraphy was used as a screening procedure. The criteria for a positive scan was an area of increased uptake of technetium extending above the normal dense uptake of stomach configuration. Pertechnetate scintigraphy was performed in 4 patients with Barrett's esophagus and 6 controls with only one false negative result. Thus pertechnetate scintigraphy is a rapid, safe, and a traumatic screening procedure.
- Research Organization:
- Monroe County Hospital, Rochester, NY
- OSTI ID:
- 7120585
- Journal Information:
- Am. J. Dig. Dis.; (United States), Vol. 21:4
- Country of Publication:
- United States
- Language:
- English
Similar Records
Technetium-99m pertechnetate as an indicator of gastric mucosal proliferation. [Evaluation of mucosal regeneration in dogs]
Adenocarcinoma of the esophagus: relationship to Barrett mucosa
Related Subjects
ESOPHAGUS
SCINTISCANNING
TECHNETIUM 99
DIAGNOSTIC TECHNIQUES
ISOMERIC NUCLEI
PATIENTS
PERTECHNETATES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DIGESTIVE SYSTEM
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics