Ability of PABA to protect mammalian skin from ultraviolet light-induced skin tumors and actinic damage
Journal Article
·
· J. Invest. Dermatol.; (United States)
Application of 5% para-aminobenzoic acid (PABA) to hairless mice one hour prior to ultraviolet light (UVL) irradiation will almost totally protect these animals from developing tumors induced by chronic exposure to UVL in the 290 to 320 nm range in conjunction with a chemical carcinogen. Mice exposed to UVL and not protected by PABA developed primarily squamous cell carcinomas. Two months after cessation of chronic UVL exposure, the non-PABA-treated irradiated mouse skin appeared thickened, yellow, and wrinkled while showing elevated DNA synthesis, hyperplasia, hypergranulosis, and increased amounts of elastotic material. The PABA-treated skin was grossly normal.
- Research Organization:
- Univ. of Miami, FL
- OSTI ID:
- 7120472
- Journal Information:
- J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 65:6; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CARCINOGENESIS
CARCINOMAS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
IRRADIATION
MAMMALS
MICE
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PABA
PATHOGENESIS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOINDUCTION
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SKIN
ULTRAVIOLET RADIATION
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CARCINOGENESIS
CARCINOMAS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
IRRADIATION
MAMMALS
MICE
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PABA
PATHOGENESIS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOINDUCTION
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SKIN
ULTRAVIOLET RADIATION
VERTEBRATES