Xeroderma pigmentosum: biochemical and genetic characteristics

Journal Article · Tue Dec 31 23:00:00 EST 1974 · Annu. Rev. Genet.; (United States)

DOI:https://doi.org/10.1146/annurev.ge.09.120175.000315· OSTI ID:7110279

Cleaver, J E ^[1]; Bootsma, D

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1. Univ. of California, San Francisco

Biochemical and genetic studies on xeroderma pigmentosum are reviewed under the following headings: clinical features of xeroderma pigmentosum; karyotype; cell killing and host cell reactivation after irradiation or exposure to chemical carcinogens; SV40 transformation of xeroderma pigmentosum cells; biochemical defects in the common and de Sanctis-Cacchione forms of xeroderma pigmentosum; cell hybridization and complementation groups; biochemical defects in the xeroderma pigmentosum variant and the role of caffeine in DNA repair; DNA repair in xeroderma pigmentosum heterozygotes; response of xeroderma pigmentosum cells to various mutagens and chemical carcinogens; other high and low repair diseases; and possible significance of DNA repair in theories of aging and carcinogenesis. (HLW)

• OSTI ID: 7110279
• Journal Information: Annu. Rev. Genet.; (United States), Journal Name: Annu. Rev. Genet.; (United States) Vol. 9; ISSN ARUGB
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOLOGY
CAFFEINE
CARCINOGENS
CELL KILLING
CHEMISTRY
DISEASES
DNA
DOCUMENT TYPES
DRUGS
GENETICS
HETEROCYCLIC COMPOUNDS
HYBRIDIZATION
KARYOTYPE
MUTAGENS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
RADIATION EFFECTS
RECOVERY
REPAIR
REVIEWS
SKIN DISEASES
XANTHINES