Effect of NO/sub 2/ on erythrocyte glucose metabolism as related to changes in redox ratio (NAD/sup +/)/(NADH)

Journal Article · Fri Oct 01 04:00:00 EDT 1976 · Environ. Res.; (United States)

OSTI ID:7110058

Cassan, S M; Gross, B; Simmons, D H

Glucose utilization of human erythrocytes increased to approximately 2.5 times control values when exposed to a mean NO/sub 2/ concentration of 336.6 ppM for 2 hours at 37/sup 0/C and pH = 7.23. The fraction of glucose utilized by the pentose phosphate pathway remained constant so that actual glucose utilized by both this pathway and by glycolysis increased in proportion to the total glucose metabolized. The rate of total lactate plus pyruvate production remained unchanged. These data suggest that NO/sub 2/ may influence several loci of erythrocyte metabolism, including accumulation of glycolytic intermediates proximal to the reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase, oxidation of NADH, NADPH, and GSH, and alteration of NADH dependent enzymes.

• Research Organization: Univ. of California, Los Angeles
• OSTI ID: 7110058
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 12:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CARBOXYLIC ACIDS
CATALYSIS
CHALCOGENIDES
CHEMICAL REACTIONS
COENZYMES
DECOMPOSITION
DEHYDROGENASES
ENZYMES
ERYTHROCYTES
GLUCOSE
GLYCOLYSIS
HEXOSES
HYDROXY ACIDS
KETO ACIDS
KINETICS
LACTIC ACID
MAMMALS
MAN
METABOLISM
MONOSACCHARIDES
NAD
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDATION
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PENTOSES
PH VALUE
PHOSPHATES
PHOSPHORUS COMPOUNDS
PRIMATES
PYRUVIC ACID
REACTION KINETICS
SACCHARIDES
SYNTHESIS
TEMPERATURE DEPENDENCE
VERTEBRATES