Effect of mass-transfer kinetics on the elution of a binary mixture in nonlinear liquid chromatography

Journal Article · Thu Sep 07 04:00:00 EDT 1989 · Journal of Physical Chemistry; (USA)

DOI:https://doi.org/10.1021/j100355a059· OSTI ID:7108563

Golshan-Shirazi, S; Lin, B; Guiochon, G ^[1]

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1. Oak Ridge National Lab., TN (USA)

A procedure for calculating numerical solutions of the nonlinear, nonequilibrium model of chromatography for a two-component mixture is described. Solutions are presented and discussed for a series of numerical values corresponding to a wide range of mass-transfer kinetics for either component. When the mass-transfer kinetics is not very slow, the band profiles are controlled by the thermodynamic effects and the solutions are identical with those obtained by solution of the corresponding semiideal model. When the kinetics becomes slow, the nonlinear thermodynamic effects decrease and vanish. The retention time of the maximum of the band profile first increases, then decreases, and eventually a bimodal band appears, with the second maximum eluted with nonretained compounds. When the mass-transfer kinetics of the two components are very different, elution profiles are complex. The coupling effect between the two bands disappears rapidly if the component which has the larger concentration is the one with the very slow kinetics. As the opposite of the semiideal model, previously discussed, this model permits an accurate prediction of the elution profiles of the components of a mixture when their mass-transfer coefficients are different.

• OSTI ID: 7108563
• Journal Information: Journal of Physical Chemistry; (USA), Journal Name: Journal of Physical Chemistry; (USA) Vol. 93:18; ISSN 0022-3654; ISSN JPCHA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400000* -- Chemistry
400200 -- Inorganic
Organic
& Physical Chemistry
BINARY MIXTURES
CALCULATION METHODS
CHROMATOGRAPHY
DISPERSIONS
KINETICS
LIQUID COLUMN CHROMATOGRAPHY
MASS TRANSFER
MATHEMATICAL MODELS
MIXTURES
NUMERICAL SOLUTION
REACTION KINETICS
SEPARATION PROCESSES