(. mu. -1,1 prime -Bis(diphenylphosphine)ferrocene)bis(chlorogold): Synthesis, iron-57 and gold-197 Moessbauer spectroscopy, x-ray crystal structure, and antitumor activity

Journal Article · Wed Sep 06 04:00:00 EDT 1989 · Inorganic Chemistry; (USA)

DOI:https://doi.org/10.1021/ic00317a027· OSTI ID:7108010

Hill, D T; Girard, G R; McCabe, F L; Johnson, R K; Eggleston, D S ^[1]; Stupik, P D; Zhang, J H; Reiff, W M ^[2]

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1. Smith Kline and French Labs., King of Prussia, PA (USA)
2. Northeastern Univ., Boston, MA (USA)

The title compound 2, Fdpp(AuCl){sub 2}, synthesized via the addition of Fdpp (1) to an aqueous solution of ((HOCH{sub 2}CH{sub 2}){sub 2}S)AuCl generated in situ by the thiodiglycol reduction of HAuCl{sub 4} showed a {sup 31}P({sup 1}H) NMR chemical shift at {delta} 27.39, which was downfield from that of 1 at {delta} -17.34 relative to (CH{sub 3}O)PO. The {sup 57}Fe Moessbauer spectrum of 2 is a doublet with parameters (IS = 0.50 mm/s relative to Fe, QS = 2.33 mm/s) similar to those of ferrocene. The {sup 197}Au Moessbauer spectrum of 2 is an asymmetric doublet (QS = 6.93 mm/s) with an IS of 3.81 mm/s relative to Au metal. Fdpp(AuCl){sub 2} crystallized in space group P{bar 1} with lattice constants a = 16.192 (4) {angstrom}, b = 16.921 (4) {angstrom}, and c = 10.878 (5) {angstrom} with Z = 3. Two crystallographically independent molecules, A and B, were observed in the structure of 2 with a chloroform solvate molecule per 1.5 formula units of the gold complex. For A, the P atoms are 180{degree} opposed and the rings exactly staggered, while in B the P atoms are 150{degree} apart and the rings are partially staggered. The P-Au-Cl linkage is nearly linear, and the bond distances fall within normal ranges. Evaluation in an ip P388 leukemia mouse model showed 1 and 2 to have only marginal activity with an increased life span (ILS) relative to untreated controls of 30% at a maximally tolerated dose (MTD) of 231 {mu}mol/kg and 40% ILS at 4 {mu}mol/kg, respectively. 27 refs., 4 figs., 3 tabs.

• OSTI ID: 7108010
• Journal Information: Inorganic Chemistry; (USA), Journal Name: Inorganic Chemistry; (USA) Vol. 28:18; ISSN 0020-1669; ISSN INOCA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400201* -- Chemical & Physicochemical Properties
400202 -- Isotope Effects
Isotope Exchange
& Isotope Separation
550600 -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
CHLORIDES
CHLORINE COMPOUNDS
COMPLEXES
CRYSTAL STRUCTURE
DATA
DIENES
DISEASES
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
FERROCENE
GOLD 197
GOLD CHLORIDES
GOLD COMPOUNDS
GOLD ISOTOPES
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
HEMIC DISEASES
HYDROCARBONS
IMMUNE SYSTEM DISEASES
INFORMATION
INHIBITION
INTERMEDIATE MASS NUCLEI
IRON 57
IRON COMPLEXES
IRON ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKEMIA
MAMMALS
MICE
MOESSBAUER EFFECT
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
POLYENES
RADIOISOTOPES
RODENTS
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
SYNTHESIS
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES