Protein evolution on rugged landscapes

Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.86.16.6191· OSTI ID:7105821

Macken, C A ^[1]; Perelson, A S ^[2]

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1. Los Alamos National Laboratory, NM (USA)
2. Los Alamos National Laboratory, NM (USA) Sante Fe Institute, NM (USA)

The authors analyze a mathematical model of protein evolution in which the evolutionary process is viewed as hill-climbing on a random fitness landscape. In studying the structure of such landscapes, they note that a large number of local optima exist, and they calculate the time and number of mutational changes until a protein gets trapped at a local optimum. Such a hill-climbing process may underlie the evolution of antibody molecules by somatic hypermutation.

• OSTI ID: 7105821
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 86:16; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL EVOLUTION
MATHEMATICAL MODELS
PROTEINS
MOLECULAR STRUCTURE
ANTIBODIES
MOLECULAR MODELS
PROBABILITY
ORGANIC COMPOUNDS
550200* - Biochemistry