The UDP-galactose translocator gene is mapped to band Xp11. 23-p11. 22 containing the Wiskott-Aldrich Syndrome Locus

Journal Article · Mon Nov 01 04:00:00 EST 1993 · Somatic Cell and Molecular Genetics; (United States)

DOI:https://doi.org/10.1007/BF01233383· OSTI ID:7105269

Hara, Takahiko; Hoshino, Masato; Aoki, Kazuhisa; Ayusawa, Dai; Kawakita, Masao ^[1]; Yamauchi, Masatake; Takahashi, Ei-ichi ^[2]

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1. Univ. of Tokyo (Japan)
2. National Institute of Radiological Sciences, Chiba (Japan)

The authors have cloned a segment of the human gene encoding UDP-galactose translocator by genetic complementation of its defective mutant in mouse FM3A cells. Chromosome mapping using fluorescent in situ hybridization revealed that the cloned gene hybridized to the Xp11.23-11.23 region of the X chromosome. This region is shared by the locus of Wiskott-Aldrich syndrome, an X-linked recessive immunodeficiency disorder, characterized by defective sugar chains on cell surface components. Genetic and phenotypic similarities suggest a possible link between UDP-galactose translocator and the Wiskott-Aldrich syndrome (WAS).

• OSTI ID: 7105269
• Journal Information: Somatic Cell and Molecular Genetics; (United States), Journal Name: Somatic Cell and Molecular Genetics; (United States) Vol. 19:6; ISSN 0740-7750; ISSN SCMGDN
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
CARBOHYDRATES
CELL CONSTITUENTS
CHROMOSOMES
DISEASES
GENE MUTATIONS
GENETIC MAPPING
GOLGI COMPLEXES
HETEROCHROMOSOMES
HUMAN CHROMOSOMES
HUMAN X CHROMOSOME
IMMUNE SYSTEM DISEASES
MAPPING
MUTATIONS
NUCLEOTIDES
ORGANIC COMPOUNDS
SACCHARIDES
TRANSLOCATION
X CHROMOSOME