Changes in tissue glutathione and mercury concentrations in rats following mercuric chloride injection through the hepatic portal vein
- National Univ. of Singapore (Singapore)
The kidney is known as a primary target organ for mercury deposition. However, it is also known as an important organ for the elimination of the absorbed mercury. Tanaka and her collaborators showed that inorganic mercury when injected through caudal vein is transported to the kidney as mercury-GSH complex. If that is so, liver which contains the highest level of tissue GSH than any other organs in normal animals would appear to be a prime site for the complexion of mercury ions with GSH before they are released and transported to the kidney. In view of this, it is of interest to establish the interrelative changes of the amounts of GSH and mercury in between liver and kidney at the earlier time intervals after a direct injection of a low dosage of mercuric chloride (HgCl{sub 2}) into the hepatic portal vein.
- OSTI ID:
- 7104548
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (USA), Vol. 42:6; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
GLUTATHIONE
METABOLISM
MERCURY CHLORIDES
BIOLOGICAL EFFECTS
INJECTION
KIDNEYS
LIVER
PORTAL SYSTEM
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
DRUGS
GLANDS
HALIDES
HALOGEN COMPOUNDS
INTAKE
MERCURY COMPOUNDS
MERCURY HALIDES
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
VEINS
560300* - Chemicals Metabolism & Toxicology