Fast-neutron irradiation of mouse embryos in the pronuclear zygote stage: mortality curves and neoplastic diseases in 30-day postnatal survivors

Journal Article · Thu Apr 01 04:00:00 EST 1976 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-151-39312· OSTI ID:7103818

Friedberg, W ^[1]; Hanneman, G D; Faulkner, D N; Neas, B R; Cosgrove, Jr, G E; Darden, Jr, E B

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1. Civil Aeromedical Inst., Oklahoma City

Mouse embryos in the pronuclear zygote stage were either irradiated in utero with a dose of 15 rad of fast neutrons or were sham-irradiated. Those animals that survived at least 30 days after birth were observed until their natural death. The percentage incidence and mean age at death for each of the principal neoplastic diseases seen on postmortem examination and also cumulative mortality distributions was investigated. No statistically significant differences were found between irradiated and sham-irradiated mice of the same sex.

• OSTI ID: 7103818
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 151:4; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
ELEMENTARY PARTICLES
EMBRYOS
FAST NEUTRONS
FERMIONS
HADRONS
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MICE
MORTALITY
NEOPLASMS
NEUTRONS
NUCLEONS
PRENATAL IRRADIATION
RADIATION EFFECTS
RODENTS
SURVIVAL CURVES
VERTEBRATES