Peptide and amino acid separation with nanofiltration membranes

Journal Article · Sun May 01 00:00:00 EDT 1994 · Separation Science and Technology; (United States)

DOI:https://doi.org/10.1080/01496399408005611· OSTI ID:7102367

Tsuru, Toshinori; Shutou, Takatoshi; Nakao, Shin-Ichi; Kimura, Shoji ^[1]

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1. Univ. of Tokyo (Japan)

Several nanofiltration membranes [UTC-20, 60 (Toray Industries), NF-40 (Film-Tech Corporation), Desal-5, G-20 (Desalination Systems), and NTR-7450 (Nitto Electric Industrial Co.)] were applied to separate amino acids and peptides on the basis of charge interaction with the membranes since most of them contain charged functional groups. Nanofiltration membranes having a molecular weight cutoff (MWCO) below 300 (UTC-20, 60, NF-40 and Desal-5) were not suitable for separation of amino acids. On the other hand, separation of amino acids and peptides with nanofiltration membranes having a MWCO around 2000-3000 (NTR-7450 and G-20) was satisfactory based on a charge effect mechanism; charged amino acids and peptides were rejected while neutral amino acids and peptides permeated through the membranes. Separation of peptides having different isoelectric points with nanofiltration membranes was possible by adjusting the pH. 15 refs., 11 figs., 4 tabs.

• OSTI ID: 7102367
• Journal Information: Separation Science and Technology; (United States), Journal Name: Separation Science and Technology; (United States) Vol. 29:8; ISSN 0149-6395; ISSN SSTEDS
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400105* -- Separation Procedures
400201 -- Chemical & Physicochemical Properties
AMINO ACIDS
CARBOXYLIC ACIDS
COMPILED DATA
DATA
DIFFUSION
FILTRATION
INFORMATION
MEMBRANES
MOLECULAR WEIGHT
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC POLYMERS
OSMOSIS
PEPTIDES
PERMEABILITY
PH VALUE
POLYAMIDES
POLYMERS
PROTEINS
SEPARATION PROCESSES