Treatment-related central nervous system toxicity: MR imaging evaluation with CT and clinical correlation

Journal Article · Wed Nov 01 00:00:00 EST 1989 · Magnetic Resonance Imaging; (USA)

DOI:https://doi.org/10.1016/0730-725X(89)90536-5· OSTI ID:7100713

Hazuka, M B; Kinzie, J J; Davis, K A; DeBoise, D A ^[1]

---

1. Univ. of Colorado Health Sciences Center, Denver (USA)

Thirteen patients with abnormal brain MR scans attributable to treatment-induced injury were retrospectively reviewed. All patients were treated with radiation therapy and 62% received chemotherapy. Five patients were graded as having severe white matter (WM) changes, four had moderate WM changes, and four had mild WM changes. CT was generally equivalent to MR in evaluation of severe and moderate WM abnormalities, whereas MR was superior to CT in detection of mild WM abnormalities. In general, the severity of changes depicted by MR/CT correlated with the extent of neurologic dysfunction. The most severe changes were seen in those patients treated with combination irradiation and chemotherapy.

• OSTI ID: 7100713
• Journal Information: Magnetic Resonance Imaging; (USA), Vol. 7:6; ISSN 0730-725X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BRAIN
NEOPLASMS
COMBINED THERAPY
SIDE EFFECTS
DIAGNOSIS
ANTINEOPLASTIC DRUGS
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
PATIENTS
BODY
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
MAGNETIC RESONANCE
NERVOUS SYSTEM
ORGANS
RESONANCE
THERAPY
TOMOGRAPHY
550600* - Medicine
550602 - Medicine- External Radiation in Diagnostics- (1980-)
560151 - Radiation Effects on Animals- Man