Characterization and induction of aryl hydrocarbon (benzo(a)pyrene) hydroxylase in rabbit bone marrow
Journal Article
·
· Res. Commun. Chem. Pathol. Pharmacol.; (United States)
OSTI ID:7100338
Benzo(a)pyrene hydroxylase activity was found in the bone marrow of control and 3-methylcholanthrene(3MC)-induced New Zealand white rabbits. This activity was localized in the microsomal fraction, was NADPH dependent and CO sensitive. The reaction was inhibited by 7,8-benzoflavone indicating that it was mediated by the 3MC-inducible form of cytochrome P-450. BP hydroxylase activity in rabbit bone marrow was located primarily in white cells, and was considerably higher than that previously reported for cultured human lymphocytes and monocytes. A possible role for the bone marrow mixed-function oxygenase in the production of hemopoietic toxicity is considered.
- Research Organization:
- Univ. of Pennsylvania, Philadelphia
- OSTI ID:
- 7100338
- Journal Information:
- Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 15:2; ISSN RCOCB
- Country of Publication:
- United States
- Language:
- English
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Journal Article
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OSTI ID:6339911
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Conference
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Thu May 01 00:00:00 EDT 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:5322268
Metabolism of benzo(a)pyrene and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene by rat liver nuclei and microsomes
Journal Article
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Mon May 01 00:00:00 EDT 1978
· Cancer Res.; (United States)
·
OSTI ID:6789428
Related Subjects
550200* -- Biochemistry
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYL RADICALS
ANIMAL CELLS
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
BODY FLUIDS
BONE MARROW
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CATALYSIS
CELL CONSTITUENTS
CHALCOGENIDES
CHOLANTHRENE
COENZYMES
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
ENZYMES
FLAVENOIDS
FLAVONES
HEMATOPOIETIC SYSTEM
HYDROCARBONS
HYDROXYLASE
INDUCTION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
METABOLISM
METHYL RADICALS
MICROSOMES
MONOCYTES
NADP
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
RABBITS
RADICALS
SOMATIC CELLS
TISSUES
TOXICITY
VERTEBRATES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYL RADICALS
ANIMAL CELLS
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
BODY FLUIDS
BONE MARROW
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CATALYSIS
CELL CONSTITUENTS
CHALCOGENIDES
CHOLANTHRENE
COENZYMES
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
ENZYMES
FLAVENOIDS
FLAVONES
HEMATOPOIETIC SYSTEM
HYDROCARBONS
HYDROXYLASE
INDUCTION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
METABOLISM
METHYL RADICALS
MICROSOMES
MONOCYTES
NADP
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
RABBITS
RADICALS
SOMATIC CELLS
TISSUES
TOXICITY
VERTEBRATES