Ly-1 B cells and disease activity in (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation

Journal Article · Sun Apr 01 00:00:00 EST 1990 · Arthritis and Rheumatism; (USA)

DOI:https://doi.org/10.1002/art.1780330413· OSTI ID:7099676

Farinas, M C; Stall, A M; Solovera, J J; Tarlinton, D M; Herzenberg, L A; Strober, S ^[1]

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1. Stanford Univ. School of Medicine, CA (USA)

The treatment of female (New Zealand black x New Zealand white)F1 mice with total lymphoid irradiation resulted in a prolonged remission of autoimmune disease activity. Total lymphoid irradiation-treated mice also showed a marked reduction of Ly-1 B cells, which lasted up to 3 months. The subsequent return of Ly-1 B cells to preirradiation levels was not associated with a simultaneous return of disease when measured by parameters such as IgG anti-DNA antibodies and spontaneous secretion of IgG by splenic cells. In cell sorting experiments, most of the cells spontaneously secreting IgG were found within the Ly-1- (CD5-) splenic B cell population.

• OSTI ID: 7099676
• Journal Information: Arthritis and Rheumatism; (USA), Vol. 33:4; ISSN 0004-3591
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
IMMUNE SYSTEM DISEASES
RADIOTHERAPY
LYMPHATIC SYSTEM
IRRADIATION
LYMPHOCYTES
BIOLOGICAL RADIATION EFFECTS
DNA
INHIBITION
LYMPH NODES
MICE
SPLEEN
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
LEUKOCYTES
MAMMALS
MATERIALS
MEDICINE
NUCLEAR MEDICINE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOLOGY
RODENTS
SOMATIC CELLS
THERAPY
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)