Comparative study of the tissue distribution of NADH and NADPH-dependent chloral hydrate reducing enzymes in the rat
Journal Article
·
· Bulletin of Environmental Contamination and Toxicology; (USA)
- Yamaguchi Univ. School of Medicine, Kogushi Ube (Japan)
Chloral hydrate (CH), an intermediate metabolite of trichloroethylene, is reduced to trichloroethanol (TCE) by alcohol dehydrogenase and aldehyde reductase. Alcohol dehydrogenase requires reduced nicotinamide adenine dinucleotide (NADH), and aldehyde reductase requires reduced nicotinamide adenine dinucleotide phosphate (NADPH). No reports have appeared concerning comparative studies of the tissue distribution of CH-reducing enzymes. In this report, NADH and NADPH-dependent CH-reducing activities were investigated in various organs of the rat.
- OSTI ID:
- 7098759
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (USA), Journal Name: Bulletin of Environmental Contamination and Toxicology; (USA) Vol. 44:3; ISSN 0007-4861; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ANIMALS
BODY
CHLORINATED ALIPHATIC HYDROCARBONS
COENZYMES
DIGESTIVE SYSTEM
DISTRIBUTION
ENDOCRINE GLANDS
ENZYMES
GASTROINTESTINAL TRACT
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
HEMIACETAL DEHYDROGENASES
HYDRATES
INTESTINES
KIDNEYS
LIVER
LUNGS
MAMMALS
METABOLISM
NADH2
NADP
NUCLEOTIDES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ANIMALS
BODY
CHLORINATED ALIPHATIC HYDROCARBONS
COENZYMES
DIGESTIVE SYSTEM
DISTRIBUTION
ENDOCRINE GLANDS
ENZYMES
GASTROINTESTINAL TRACT
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
HEMIACETAL DEHYDROGENASES
HYDRATES
INTESTINES
KIDNEYS
LIVER
LUNGS
MAMMALS
METABOLISM
NADH2
NADP
NUCLEOTIDES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
VERTEBRATES