Comparison of normal and asthmatic subjects' responses to sulfate pollutant aerosols
Epidemiological studies support an association between elevated levels of sulfates and acute respiratory disease. To determine if these pollutants produce airway hyperreactivity, 16 normal and 17 asthmatic subjects inhaled a control NaCl aerosol and the following sulfates: ammonium sulfate, sodium bisulfate, ammonium bisulfate, and sulfuric acid. A Lovelace generator produced particles with an average MMAD of approx. 1.0 ..mu..m (sigma/sub g/ approx. = 2.0) and concentrations of 0.1 and 1.0 mg/m/sup 3/. By double-blind randomization, all subjects breathed these aerosols for a 16-minute period. To determine if sulfate inhalation caused increased reactivity to a known bronchoconstrictor, all subjects inhaled carbachol following each 16-minute exposure. Before, during, and after exposure, pulmonary function studies were performed. When compared to NaCl, sulfate (1 mg/m/sup 3/) produced significant reductions in airway conductance and flow rates in asthmatics. The two most sensitive asthmatics demonstrated changes even at 0.1 mg/m/sup 3/ sulfate. To a far more significant degree, the bronchoconstrictor action of carbachol was potentiated by sulfates more or less in relation to their acidity in normals and asthmatics.
- Research Organization:
- Rochester Univ., NY (USA). Dept. of Radiation Biology and Biophysics
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 7096979
- Report Number(s):
- UR-3490-1886; CONF-8009111-1
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID SULFATES
AEROSOLS
ALKALI METAL COMPOUNDS
AMMONIUM COMPOUNDS
ANIMALS
ASTHMA
BIOLOGICAL EFFECTS
CHLORIDES
CHLORINE COMPOUNDS
COLLOIDS
COMPARATIVE EVALUATIONS
CORRELATIONS
DISEASES
DISPERSIONS
EPIDEMIOLOGY
HALIDES
HALOGEN COMPOUNDS
HYDROGEN COMPOUNDS
INHALATION
INORGANIC ACIDS
INTAKE
MAMMALS
MAN
OXYGEN COMPOUNDS
PRIMATES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SENSITIVITY
SODIUM CHLORIDES
SODIUM COMPOUNDS
SOLS
SULFATES
SULFUR COMPOUNDS
SULFURIC ACID
VERTEBRATES