Thallium-201 SPECT in coronary artery disease patients with left bundle branch block
Fourteen patients with left bundle branch block (LBBB) underwent immediate postexercise and 3-hr delayed /sup 201/Tl single photon emission computed tomography (SPECT) with quantitative analysis using bullseye polar maps. Test performance in detecting individual coronary artery stenosis greater than or equal to 50% demonstrated 100% sensitivity. Specificity was 100% for circumflex stenosis, 78% for right coronary stenosis, but only 10% for left anterior descending coronary stenosis. This very low specificity was due to the fact that 3/4 (75%) patients with left anterior descending stenosis and also 9/10 (90%) patients with normal left anterior descending coronary arteries had immediate septal perfusion defects with redistribution in all cases at 3 hr. Septal abnormalities were most marked in patients who achieved high peak heart rates (greater than 170 bpm). Thus, with LBBB, /sup 201/Tl SPECT is indeterminate for left anterior descending coronary disease.
- Research Organization:
- Emory Univ. School of Medicine, Atlanta, GA (USA)
- OSTI ID:
- 7095148
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 29:9
- Country of Publication:
- United States
- Language:
- English
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