Fluorine-18-N-methylspiroperidol: radiolytic decomposition as a consequence of high specific activity and high dose levels

Journal Article · Wed Dec 31 23:00:00 EST 1986 · J. Nucl. Med.; (United States)

OSTI ID:7093776

MacGregor, R R; Schlyer, D J; Fowler, J S; Wolf, A P; Shiue, C Y

High specific activity (/sup 18/F)N-methylspiroperidol(8-(4-(4-(18F)fluorophenyl)-4-oxobutyl)-3-me thyl l-1-phenyl-1,3,8-triazaspiro(4.5)decan-4-one, 5-10 mCi/ml, 4-8 Ci/mumol at EOB) in saline solution undergoes significant radiolytic decomposition resulting in a decrease in radiochemical purity of 10-25% during the first hour. The rate of decomposition is affected by the specific activity, total dose to and chemical composition of the solution. That radiolysis is responsible for the observed decomposition was verified by the observation that unlabeled N-methylspiroperidol is decomposed in the presence of (18F)fluoride.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 7093776
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 1; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIDEPRESSANTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
CONTROL
DECOMPOSITION
DIAGNOSTIC TECHNIQUES
DISPERSIONS
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MIXTURES
NUCLEI
ODD-ODD NUCLEI
PSYCHOTROPIC DRUGS
QUALITY CONTROL
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIOCHEMISTRY
RADIOISOTOPES
RADIOLYSIS
SOLUTIONS
TOMOGRAPHY