Normal level of unscheduled DNA synthesis in Werner's syndrome fibroblasts in culture
Journal Article
·
· Exp. Cell Res.; (United States)
We investigated UV-induced unscheduled DNA synthesis (UDS) in skin fibroblasts from seven unrelated patients with clinically apparent Werner's syndrome (WS). WS cells exhibited greatly abbreviated in vitro lifespans, the extents of which ranged from about 20 to 50% of the normal. However, WS cells in early and senescent phases of growth showed the same quantity of DNA repair following UV exposure as did normal fibroblasts.
- Research Organization:
- Kobe Univ. School of Medicine (Japan)
- OSTI ID:
- 7092100
- Journal Information:
- Exp. Cell Res.; (United States), Journal Name: Exp. Cell Res.; (United States) Vol. 113:2; ISSN ECREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CELL CULTURES
CONNECTIVE TISSUE CELLS
DISEASES
DNA REPAIR
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
IN VITRO
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SKIN
SKIN DISEASES
SOMATIC CELLS
ULTRAVIOLET RADIATION
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CELL CULTURES
CONNECTIVE TISSUE CELLS
DISEASES
DNA REPAIR
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
IN VITRO
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SKIN
SKIN DISEASES
SOMATIC CELLS
ULTRAVIOLET RADIATION