Pulmonary function in normal and elastase-treated hamsters exposed to a complex mixture of olefin-ozone-sulfur dioxide reaction products
An elastase-induced emphysema model was utilized to determine if hamsters with preexisting lung disease were more susceptible to lung damage from air-pollutant exposure. Male golden hamsters, divided into two treatment groups, were given a single intratracheal injection of either 6 units of porcine pancreatic elastase (EMP) or buffer (CNT). After a 4-week recovery period, equal numbers of each group were exposed 23 hr/day x 28 day to filtered air (AIR) or to the complex by-products from a dark-phase-reaction mixture of trans-2-butene, ozone, and sulfur dioxide (MIX). Lung-function measurements on the elastase-treated groups showed changes consistent with mild emphysema. There were no significant differences in lung volumes or lung compliance between the AIR- and MIX-exposed animals. However, the nitrogen washout slope decreased and the diffusing capacity for carbon monoxide increased in both the CNT and EMP hamsters exposed to the MIX. The change in diffusing capacity was greater in normal hamsters than in hamsters with emphysema, and it is hypothesized that animals with impaired lung function had a decreased ability to respond to a pulmonary insult from the mix.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 7090877
- Report Number(s):
- PB-88-233945/XAB; EPA-600/J-83/328
- Resource Relation:
- Other Information: Pub. in Environmental Research, Vol. 31, 302-310(1983)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
54 ENVIRONMENTAL SCIENCES
ALKENES
BIOLOGICAL EFFECTS
OZONE
RESPIRATORY SYSTEM DISEASES
SULFUR DIOXIDE
AIR POLLUTION
EMPHYSEMA
HAMSTERS
ANIMALS
CHALCOGENIDES
DISEASES
HYDROCARBONS
MAMMALS
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RODENTS
SULFUR COMPOUNDS
SULFUR OXIDES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)