Autoradiographic localization of /sup 3/H-dihydrotestosterone in the preoptic area, hypothalamus, and amygdala of a male rhesus monkey
Journal Article
·
· Life Sci.; (United States)
In a preliminary study, autoradiography was used to localize target cells for /sup 3/H-dihydrotestosterone (DHT), a non-aromatizable androgen, in the brain of the rhesus monkey. One castrated male was injected intravenously with 2 mCi of /sup 3/H-DHT (0.42 ..mu..g/kg), and was killed one hour later. Neurons that concentrated radioactivity in their nuclei were located in widespread areas of the brain, which included the medial and suprachiasmatic preoptic nuclei, bed nucleus of the stria terminalis, lateral septal nucleus, anterior hypothalamic area, ventromedial, arcuate, dorsomedial, and paraventricular hypothalamic nuclei, ventral premammillary nucleus, and medial, cortical, basal accessory, and lateral amygdaloid nuclei. These results indicate that the topographic distribution of androgen target neurons is considerably wider than that observed in a study using /sup 3/H-testosterone (T) in the male rhesus monkey. However, further work is needed to elucidate these differences before attempting correlations between behavioral activity and androgen receptors in the brain.
- Research Organization:
- Georgia Mental Health Inst., Atlanta
- OSTI ID:
- 7089629
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 30:24; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Conference
·
Fri Feb 28 23:00:00 EST 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:5508818
Connections of the corticomedial amygdala in the golden hamster. I. Efferents of the ''vomeronasal amygdala''
Journal Article
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Thu Mar 19 23:00:00 EST 1981
· J. Comp. Neurol.; (United States)
·
OSTI ID:5705466
Connections of the corticomedial amygdala in the golden hamster. II. Efferents of the ''olfactory amygdala''
Journal Article
·
Thu Mar 19 23:00:00 EST 1981
· J. Comp. Neurol.; (United States)
·
OSTI ID:5577726
Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANDROGENS
ANDROSTANES
ANIMAL CELLS
ANIMALS
AUTORADIOGRAPHY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DISTRIBUTION
HORMONES
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
KETONES
LABELLED COMPOUNDS
MALES
MAMMALS
METABOLITES
MONKEYS
NERVE CELLS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RECEPTORS
SOMATIC CELLS
STEROID HORMONES
STEROIDS
TESTOSTERONE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANDROGENS
ANDROSTANES
ANIMAL CELLS
ANIMALS
AUTORADIOGRAPHY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DISTRIBUTION
HORMONES
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
KETONES
LABELLED COMPOUNDS
MALES
MAMMALS
METABOLITES
MONKEYS
NERVE CELLS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RECEPTORS
SOMATIC CELLS
STEROID HORMONES
STEROIDS
TESTOSTERONE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES