Adjunctive therapy with interstitial irradiation for prostate cancer

Journal Article · Wed Mar 31 23:00:00 EST 1982 · Urology (Ridgewood, N.J.); (United States)

DOI:https://doi.org/10.1016/0090-4295(82)90196-0· OSTI ID:7087747

deVere White, R; Babaian, R K; Feldman, M; Krane, R J; Olsson, C A

Thirty patients with clinically localized adenocarcinoma of the prostate underwent simultaneous staging pelvic lymphadenectomy and interstitial irradiation. Patients were followed for eighteen to forty-five months with regard to progression of disease and development of long-term complications. Upstaging to Stage D1 by virtue of discovering pelvic node involvement was noted in 16 patients (53.3 per cent). Subsequent disease progression (defined as development of bone or soft tissue metastasis) was seen in 9 of 16 upstaged patients with an average time to progression of 12.2 months. Three Stage D1 patients have died with an average time to death of 19.6 months. Only 1 patient whose lymphadenectomy was negative has experienced disease progression, and none has died. Adjuvant chemotherapy (cyclophosphamide and doxorubicin hydrochloride) was given to 9 upstaged patients, in only 3 did disease progress. In contrast, in 6 of 7 upstaged patients not receiving chemotherapy metastatic disease developed, with an average time to progression of 10.3 months. In an attempt to improve local tumor control achieved by interstitial irradiation alone, 18 patients received additional external beam radiation therapy to the prostate, in doses ranging from 2,000 to 4,000 rad. There were sixteen long-term complications in the 30 patients, 75 per cent of which were seen in patients receiving added external beam irradiation.

• Research Organization: Department of Urology/Medicine, Boston University School of Medicine, MA
• OSTI ID: 7087747
• Journal Information: Urology (Ridgewood, N.J.); (United States), Journal Name: Urology (Ridgewood, N.J.); (United States) Vol. 19:4; ISSN URGYA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
CHEMOTHERAPY
DISEASES
EXTERNAL IRRADIATION
GLANDS
IRRADIATION
LYMPH NODES
LYMPHATIC SYSTEM
MALE GENITALS
MEDICINE
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PROSTATE
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY