Myocardial perfusion by dynamic positron emission tomography (PET) using O-15-water
Water labeled with 0-15 (2.0 m half-life) can be used as a diffusible tracer to quantitate regional myocardial perfusion using PET and bolus injections (i.v.). This is the first report of the validation of a dynamic PET method wherein both the input and residue functions are discerned simultaneously without using arterial sampling. These studies underpin noninvasive myocardial perfusion studies with an inert diffusible tracer in which variability in physiological extraction with altered flows or ischemic conditions is not a concern as with Rb-82 and N-13 ammonia. A 7 s bolus venous injection of 0-15 (up to 20 mCi) was done simultaneously with left atrial infusion of microspheres in all 4 thoracotomized dogs. 0-15 was produced by the N-14(d,n)0-15 reaction at the 88-inch cyclotron. The input function is measured from the activity in a region of interest (ROI) over the left ventricular blood pool from sequential PET images (2.5 s intervals for 60 s; 10 s for 80 s; 20 s for 160 s totalling 5 min). The 0-15 water residue function is determined from the ROI over the myocardium as determined from a Rb-82 PET study. These two data sets are used to calculate rate constants in a two-compartment model which lumps the capillary and myocite membrane transport. This model is equivalent to the basic diffusible tracer equation for variable input. The rate constant k is related to flow via a partition coefficient of 0.91 and the tissue density of 1.05g/cc. In 9 studies with 4 dogs under normal and dipyridamole-induced high flow studies the authors found an excellent correlation (r=0.8) between PET water perfusion results and flow determined form the microsphere reference organ technique.
- Research Organization:
- Donner Lab., Univ. of California, Berkeley, CA
- OSTI ID:
- 7087343
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DOGS
MYOCARDIUM
MYOCARDIAL INFARCTION
DIAGNOSIS
POSITRON COMPUTED TOMOGRAPHY
OXYGEN 15
DIAGNOSTIC USES
TRACER TECHNIQUES
WATER
LABELLING
AMMONIA
EQUATIONS
EXTRACTION
IMAGE PROCESSING
MICROSPHERES
NITROGEN 13
RUBIDIUM 82
ALKALI METAL ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HEART
HOURS LIVING RADIOISOTOPES
HYDRIDES
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
PROCESSING
RADIOISOTOPES
RUBIDIUM ISOTOPES
SEPARATION PROCESSES
TOMOGRAPHY
USES
VERTEBRATES
550602* - Medicine- External Radiation in Diagnostics- (1980-)
550601 - Medicine- Unsealed Radionuclides in Diagnostics