Proposed method to study the factors affecting local control with combined external beam and interstitial implantation of mobile tongue and floor of mouth

Journal Article · Mon Dec 01 04:00:00 EST 1986 · J. Surg. Oncol.; (United States)

DOI:https://doi.org/10.1002/jso.2930330415· OSTI ID:7086924

Hintz, B L; Kagan, A R; Chan, P; Rao, A R; Nussbaum, H; Ryoo, M C; Wollin, M

Twenty-seven patients with squamous cell carcinoma of the mobile tongue and floor of the mouth were treated with external beam and interstitial radiation. Good prognostic factors were T1N0, T2N0, superficial tumors, tumor shrinkage by 75% with external beam, and no apparent tumor clinically 2 months after treatment. On the other hand, T3N0, T1-3N1, and deeply necrotic tumors had a poor prognosis. We recommend using a flexible afterloading system to implant the initial local tumor volume (not just the residual nidus) that does not exceed 45 cm3. The minimum (reference) dose was prescribed to a surface 1/2 cm beyond the most peripheral rim of radioactive sources. For acceptable local control and complication rates, our suggested minimum (reference) doses are less than or equal to 7500 rads for T1 (or a time-dose-fractionation (TDF) of 131-140), less than or equal to 8000 rads for T2 (TDF of 131-140), and probably less than 8500 rads for T3 (TDF of less than or equal to 150). These guidelines should be considered preliminary.

• Research Organization: Southern California Permanente Medical Group, Los Angeles
• OSTI ID: 7086924
• Journal Information: J. Surg. Oncol.; (United States), Journal Name: J. Surg. Oncol.; (United States) Vol. 4; ISSN JSONA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AFTERLOADING
BODY
CARCINOMAS
DIGESTIVE SYSTEM
DISEASES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORAL CAVITY
ORGANS
PATIENTS
RADIOLOGY
RADIOTHERAPY
THERAPY
TONGUE