Late ultrastructural changes in the mouse coronary arteries and aorta after fission neutron or /sup 60/Co. gamma. irradiation

Journal Article · Thu Jun 01 00:00:00 EDT 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574860· OSTI ID:7085984

Yang, V V; Stearner, S P; Ainsworth, E J

The ultrastructure of the coronary arteries and the aorta of the B6CF/sub 1/ mouse from 1 to 24 months after irradiation is described. Radiation treatment, initiated at 4 months of age, included single total-body doses of 788 ..gamma.. rad or 240 fission neutron rad, and fractionated total-body doses of 823 ..gamma.. rad or 240 fission neutron rad (24 fractions given in 23 weeks). In addition, mice given the high ..gamma.. dose of 2690 rad (fractionated), and relatively low neutron doses (80 rad single and 20 or 80 rad fractionated) were studied at 18 months after initiation of irradiation in order to increase the dose range for estimation of the relative biological effectiveness (RBE). In control mice, at 12 months into the experiment, there was little evidence of degeneration of the coronary arteries and aorta. At 18 months, these vessels showed a slight amount of smooth muscle degeneration and fibrosis, while at 24 months lesions were more severe and there was relatively less distinction between control and treated groups (788 ..gamma.. rad or 240 neutron rad). Degenerative changes in the larger coronary arteries and the aorta first appeared at 3 to 6 months after irradiation, and became progressively more severe at later times (12 to 24 months). The major changes included smooth muscle degeneration, fibrosis, and accumulations of debris and extracellular matrix.

• Research Organization: Argonne National Lab., IL
• OSTI ID: 7085984
• Journal Information: Radiat. Res.; (United States), Vol. 74:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE IRRADIATION
RADIOSENSITIVITY EFFECTS
AORTA
DELAYED RADIATION EFFECTS
ULTRASTRUCTURAL CHANGES
CORONARIES
FISSION NEUTRONS
RBE
FRACTIONATED IRRADIATION
GAMMA RADIATION
DOSE-RESPONSE RELATIONSHIPS
RADIOINDUCTION
COBALT 60
COMPARATIVE EVALUATIONS
KEV RANGE 100-1000
MICE
WHOLE-BODY IRRADIATION
ACUTE EXPOSURE
ANIMALS
ARTERIES
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD VESSELS
CARDIOVASCULAR SYSTEM
COBALT ISOTOPES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENERGY RANGE
EXTERNAL IRRADIATION
FERMIONS
HADRONS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KEV RANGE
MAMMALS
MINUTES LIVING RADIOISOTOPES
MORPHOLOGICAL CHANGES
NEUTRONS
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals