Separation of carrier-free holmium-166 from neutron-irradiated dysprosium targets

Journal Article · Thu Dec 01 04:00:00 EST 1994 · Analytical Chemistry (Washington); (United States)

DOI:https://doi.org/10.1021/ac00095a024· OSTI ID:7079364

Dadachova, E; Lambrecht, R M; Hetherington, E L ^[1]; Mirzadeh, S; Knapp, Jr, F F ^[2]

---

1. ANSTO, Menai, New South Wales (Australia)
2. Oak Ridge National Lab., TN (United States)

Holmium-166 ([sup 166]Ho, t[sub 1/2] = 26.4 h) is utilized in radiotherapeutic applications such as radioimmunospecific pharmaceuticals, bone marrow ablation, and radiation synovectomy. High specific activity [sup 166]Ho can be obtained from the decay of dysprosium-166 ([sup 166]Dy, t[sub 1/2] = 81.5 h). Dysprosium-166 is produced by the [sup 164]Dy[n,[gamma]][sup 165]Dy[n,[gamma]][sup 166]Dy reaction in a nuclear reactor. The applicability of reversed phase ion-exchange chromatographic methods was demonstrated for the separation of carrier-free [sup 166]Ho from milligram quantities of [sup 164]Dy[sub 2]O[sub 3] irradiated targets. An efficient and quantitative separation was achieved utilizing a metal-free HPLC system with Dowex AG 50WX12 or Aminex-A5 cation exchangers and [alpha]-hydroxy-isobutyric acid ([alpha]-HIBA) as the eluent (0.085 M, pH = 4.3 adjusted with NH[sub 4]OH). The Aminex-A5 column gave a separation factor of approximately 10[sup 3] between Ho and Dy. Subsequent to the acidic destruction of the Ho-HIBA complex, Ho[sup 3+] was further purified on a small cation-exchange column from acidic chloride solutions. The separation was achieved within 2 h, with a 95% overall radiochemical yield for carrier-free [sup 166]Ho with a Dy breakthrough of < 0.1%. 32 refs., 7 figs., 1 tab.

• DOE Contract Number: AC05-84OR21400
• OSTI ID: 7079364
• Journal Information: Analytical Chemistry (Washington); (United States), Journal Name: Analytical Chemistry (Washington); (United States) Vol. 66:23; ISSN ANCHAM; ISSN 0003-2700
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400102 -- Chemical &amp; Spectral Procedures
400702* -- Radiochemistry &amp; Nuclear Chemistry-- Properties of Radioactive Materials
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHALCOGENIDES
CHROMATOGRAPHY
COMPLEXES
DAYS LIVING RADIOISOTOPES
DYSPROSIUM 164 TARGET
DYSPROSIUM 166
DYSPROSIUM COMPOUNDS
DYSPROSIUM ISOTOPES
DYSPROSIUM OXIDES
ELEMENTARY PARTICLES
ENRICHED URANIUM REACTORS
EVEN-EVEN NUCLEI
FERMIONS
HADRONS
HEAVY WATER COOLED REACTORS
HEAVY WATER MODERATED REACTORS
HFIR REACTOR
HIFAR REACTOR
HOLMIUM 166
HOLMIUM COMPLEXES
HOLMIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ION EXCHANGE MATERIALS
IRRADIATION REACTORS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION REACTORS
ISOTOPES
LIQUID COLUMN CHROMATOGRAPHY
MATERIALS
MATERIALS TESTING REACTORS
MEDICINE
NEUTRONS
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RARE EARTH COMPLEXES
RARE EARTH COMPOUNDS
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
SECONDS LIVING RADIO
SEPARATION PROCESSES
SPECTROPHOTOMETRY
TANK TYPE REACTORS
TARGETS
TEST REACTORS
THERAPY
THERMAL
THERMAL REACTORS
WATER COOLED REACTORS
WATER MODERATED REACTORS