Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Normal serum reduces whole body x-irradiation enhanced growth of a mammary carcinoma in rats

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
;

Whole body X-irradiation (WBI) of experimental animals prior to transplantation of strongly immunogenic tumors frequently results in acceleration of tumor growth because of host immunosuppression. The growth of primary tumor (p < 0.01) and metastatic tumor (p = 0.006) can be enhanced by WBI (500 to 600 rad) of W/FU rats one day prior to inoculation with syngeneic ME/H mammary carcinoma cells that previously had been shown to be weakly- or non-immunogenic by usual excision-challenge methods. Spleen cells removed 1 day post WBI contained an increased proportion of neutrophilic granulocytes, increased capacity for in vitro cell mediated cytotoxicity, and caused enhanced growth of primary and metastatic tumor in the Winn assay. Normal serum injections post WBI abrogated irradiation-enhanced tumor growth and irradiation-enhanced neutrophilic granulocytes. We suggest that both enhanced tumor growth in vivo and enhanced cell-mediated cytotoxicity in vitro are mediated by increased levels of neutrophilic granulocytes, presumably because of radiation destruction of a granulopoeisis inhibiting factor present in serum, which is restorable by normal serum.

Research Organization:
New York Medical Coll., Valhalla
OSTI ID:
7078994
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:5; ISSN IOBPD
Country of Publication:
United States
Language:
English

Similar Records

Spleen cells of whole body x-irradiated W/Fu rats enhance tumor growth in vivo and non-specific cytotoxicity in vitro
Journal Article · Thu Jan 31 23:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:5005372
Cell-mediated cytotoxicity to Moloney sarcoma in syngeneic and allogeneic rats
Journal Article · Tue Dec 31 23:00:00 EST 1974 · Int. J. Cancer; (United States) · OSTI ID:7319240
Effect of cadmium exposure on primary tumor growth and cell-mediated cytotoxicity in mice bearing MSB sarcomas
Journal Article · Wed Aug 01 00:00:00 EDT 1979 · J. Natl. Cancer Inst.; (United States) · OSTI ID:5367583

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GLANDS
GROWTH
IMMUNE SERUMS
IMMUNITY
IMMUNOSUPPRESSION
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
MAMMALS
MAMMARY GLANDS
MATERIALS
METASTASES
NEOPLASMS
ORGANS
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
TRANSPLANTS
TUMOR CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION