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Title: Mapping of the gene encoding the melanocortin-1 ([alpha]-melanocyte stimulating hormone) receptor (MC1R) to human chromosome 16q24. 3 by fluorescence in situ hybridization

Abstract

[alpha]-Melanocyte stimulating hormone ([alpha]-MSH), a hormone originally named for its ability to regulate pigmentation of melanocytes, is a 13-amino-acid post-translational product of the pro-opiomelanocortin (POMC) gene. [alpha]-MSH and the other products of POMC processing, which share the core heptapeptide amino acid sequence Met-Glu (Gly)-His-Phe-Arg-Trp-Gly (Asp), the adrenocorticotropic hormone (ACTH), [beta]-MSH, and [gamma]-MSH, are collectively referred to as melanocortins. While best known for their effects on the melanocyte (pigmentation) and adrenal cortical cells (steroidogenesis), melanocortins have been postulated to function in diverse activities, including enhancement of learning and memory, control of the cardiovascular system, analgesia, thermoregulation, immunomodulation, parturition, and neurotrophism. To identify the chromosomal band encoding the human melanocortin-1 receptor gene, 1 [mu]g of an EMBL clone coding region of the human MC1R and approximately 15 kb of surrounding DNA was labeled with biotin and hybridized to human metaphase chromosomes as previously described. The results indicate that the human MC1R gene is localized to 16q24.3. 15 refs., 1 fig.

Authors:
; ; ; ; ; ;  [1]
  1. (Univ. of Michigan Medical Center, Ann Arbor, MI (United States))
Publication Date:
OSTI Identifier:
7077502
Resource Type:
Journal Article
Resource Relation:
Journal Name: Genomics; (United States); Journal Volume: 19:2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; HUMAN CHROMOSOME 16; GENETIC MAPPING; PITUITARY HORMONES; GENES; ANIMAL CELLS; DNA HYBRIDIZATION; MELANIN; CHROMOSOMES; HORMONES; HUMAN CHROMOSOMES; HYBRIDIZATION; HYDROXY COMPOUNDS; MAPPING; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PEPTIDE HORMONES; PIGMENTS; PROTEINS; 550400* - Genetics

Citation Formats

Gantz, I., Yamada, Tadataka, Tashiro, Takao, Konda, Yoshitaka, Shimoto, Yoshimasa, Miwa, Hiroto, and Trent, J.M. Mapping of the gene encoding the melanocortin-1 ([alpha]-melanocyte stimulating hormone) receptor (MC1R) to human chromosome 16q24. 3 by fluorescence in situ hybridization. United States: N. p., 1994. Web. doi:10.1006/geno.1994.1080.
Gantz, I., Yamada, Tadataka, Tashiro, Takao, Konda, Yoshitaka, Shimoto, Yoshimasa, Miwa, Hiroto, & Trent, J.M. Mapping of the gene encoding the melanocortin-1 ([alpha]-melanocyte stimulating hormone) receptor (MC1R) to human chromosome 16q24. 3 by fluorescence in situ hybridization. United States. doi:10.1006/geno.1994.1080.
Gantz, I., Yamada, Tadataka, Tashiro, Takao, Konda, Yoshitaka, Shimoto, Yoshimasa, Miwa, Hiroto, and Trent, J.M. 1994. "Mapping of the gene encoding the melanocortin-1 ([alpha]-melanocyte stimulating hormone) receptor (MC1R) to human chromosome 16q24. 3 by fluorescence in situ hybridization". United States. doi:10.1006/geno.1994.1080.
@article{osti_7077502,
title = {Mapping of the gene encoding the melanocortin-1 ([alpha]-melanocyte stimulating hormone) receptor (MC1R) to human chromosome 16q24. 3 by fluorescence in situ hybridization},
author = {Gantz, I. and Yamada, Tadataka and Tashiro, Takao and Konda, Yoshitaka and Shimoto, Yoshimasa and Miwa, Hiroto and Trent, J.M.},
abstractNote = {[alpha]-Melanocyte stimulating hormone ([alpha]-MSH), a hormone originally named for its ability to regulate pigmentation of melanocytes, is a 13-amino-acid post-translational product of the pro-opiomelanocortin (POMC) gene. [alpha]-MSH and the other products of POMC processing, which share the core heptapeptide amino acid sequence Met-Glu (Gly)-His-Phe-Arg-Trp-Gly (Asp), the adrenocorticotropic hormone (ACTH), [beta]-MSH, and [gamma]-MSH, are collectively referred to as melanocortins. While best known for their effects on the melanocyte (pigmentation) and adrenal cortical cells (steroidogenesis), melanocortins have been postulated to function in diverse activities, including enhancement of learning and memory, control of the cardiovascular system, analgesia, thermoregulation, immunomodulation, parturition, and neurotrophism. To identify the chromosomal band encoding the human melanocortin-1 receptor gene, 1 [mu]g of an EMBL clone coding region of the human MC1R and approximately 15 kb of surrounding DNA was labeled with biotin and hybridized to human metaphase chromosomes as previously described. The results indicate that the human MC1R gene is localized to 16q24.3. 15 refs., 1 fig.},
doi = {10.1006/geno.1994.1080},
journal = {Genomics; (United States)},
number = ,
volume = 19:2,
place = {United States},
year = 1994,
month = 1
}
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