Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13

Journal Article · Sun Oct 31 23:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1493· OSTI ID:7076790

Ali, S T; Schappert, K; Heng, H H.Q.; Tsui, L C; Robinson, B H; Chow, W ^[1]; Duncan, M V ^[2]

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1. Univ. of Toronto, Ontario (Canada)
2. Queen's Univ., Kingston, Ontario (Canada) Kingston General Hospital, Ontario (Canada)

The 51-kDa flavoprotein subunit of mitochondrial NADH:ubiquinone oxidoreductase (Complex I) [NADH dehydrogenase (ubiquinone), flavoprotein 1 (51 kDa); EC 1.6.5.3] plays an important role in the formation of the NADH-binding site and is believed to be the principal site of entry for electrons donated by NADH into the respiratory chain. Human cDNA fragments of the 51-kDa protein were generated by polymerase chain reaction and used to localize the gene (NDUFV1) for this subunit to 11q13 by two separate techniques. This region of the human genome is strongly implicated in a number of different forms of cancer. 30 refs., 3 figs.

• OSTI ID: 7076790
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 18:2; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AROMATICS
BENZOQUINONES
CHROMOSOMES
COENZYMES
DIAPHORASE
ENZYMES
GENES
GENETIC MAPPING
HETEROCYCLIC COMPOUNDS
HUMAN CHROMOSOMES
ISOALLOXAZINES
MAPPING
NADH2
NUCLEOTIDE DEHYDROGENASES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OXIDOREDUCTASES
PROTEINS
QUINONES
UBIQUINONE