Inactivation of cathepsin B/sub 1/ by diazomethyl ketones
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
Benzyloxycarbonyl-phenylalanyl diazomethyl ketone and benzyloxy-carbonyl-phenylalanyl-phenylalanyl diazomethyl ketone, which have been shown to inactivate the thiol protease papain by a mechanism different from that of substrate chloromethyl ketone derivatives, have now been examined as inhibitors of cathepsin B/sub 1/ of beef spleen. The dipeptide derivative irreversibly inactivates this protease rapidly, apparently by affinity labeling.
- Research Organization:
- Brookhaven National Lab., Upton, NY
- OSTI ID:
- 7076091
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 79:3; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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