Insulin-like growth factor II messenger ribonucleic acids are synthesized in the choroid plexus of the rat brain
Journal Article
·
· Mol. Endocrinol.; (United States)
Previous studies demonstrating the presence of immunoreactive insulin-like growth factors (IGFs) and their receptors in the brain suggest a role of the IGFs in the central nervous system. IGF-II has been implicated as the predominant IGF in brain of mature animals based on studies of immunoreactive peptide and of IGF-II mRNAs. To obtain information about the sites of synthesis of IGF-II in adult rat brain, a /sup 32/P-labeled 31 base long synthetic oligodeoxyribonucleotide complementary in sequence to trailer peptide coding sequences in rat IGF-II mRNA (IGF-II 31 mer) was hybridized with coronal sections of fixed rat brain. The IGF-II 31 mer showed specific hybridization with the choroid plexus throughout rat brain, whereas in other brain regions, structures or cells, hybridization was not discernibly above background. These findings suggest that the choroid plexus is a primary site of synthesis of IGF-II, a probable source of IGF-II in cerebrospinal fluid, and a potential source of IGF-II for actions on target cells within the adult rat brain.
- Research Organization:
- Univ. of North Carolina, Chapel Hill (USA)
- OSTI ID:
- 7075700
- Journal Information:
- Mol. Endocrinol.; (United States), Journal Name: Mol. Endocrinol.; (United States) Vol. 2:1; ISSN MOENE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBROSPINAL FLUID
DAYS LIVING RADIOISOTOPES
GROWTH FACTORS
HORMONES
HYBRIDIZATION
IMMUNE REACTIONS
INSULIN
ISOTOPES
LIGHT NUCLEI
MAMMALS
MATERIALS
MESSENGER-RNA
MITOGENS
NERVOUS SYSTEM
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PROTEINS
RADIOISOTOPES
RATS
RNA
RODENTS
SYNTHESIS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBROSPINAL FLUID
DAYS LIVING RADIOISOTOPES
GROWTH FACTORS
HORMONES
HYBRIDIZATION
IMMUNE REACTIONS
INSULIN
ISOTOPES
LIGHT NUCLEI
MAMMALS
MATERIALS
MESSENGER-RNA
MITOGENS
NERVOUS SYSTEM
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PROTEINS
RADIOISOTOPES
RATS
RNA
RODENTS
SYNTHESIS
VERTEBRATES