Binding of lead by a pectic polyelectrolyte

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(77)90074-3· OSTI ID:7075566

Paskins-Hurlburt, A J; Tanaka, Y; Skoryna, S C; Moore, W Jr; Stara, J F

The naturally occurring polyelectrolyte, pectate, was studied for its ability to bind divalent metal cations, with specific reference to lead and calcium. Studies were carried out in vitro by ultrafiltration and in vivo by the ligated intestinal loop technique using rats. By means of the efficiency of ion-exchange reactions with divalent cations, the order of preferential binding was established for pectate. This polyelectrolyte had the greatest affinity for lead with relatively little binding of calcium. Studies in vivo demonstrate up to an 87 percent reduction in the amount of lead absorbed by the rat when using pectate. It was concluded that this naturally occurring nontoxic polyelectrolyte is a suitable binding agent for lead and that the insignificant binding of calcium is an important criteria for biological and clinical application. The high biological activity of this compound depends on position and availability of functional groups for the ion-exchange process, and viscosity of the solution.

• Research Organization: McGill Univ., Montreal
• OSTI ID: 7075566
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 14:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADSORBENTS
ALKALINE EARTH METALS
ANIMALS
BIOADSORBENTS
BIOCHEMISTRY
BIOLOGICAL ACCUMULATION
CALCIUM
CARBOHYDRATES
CATIONS
CHARGED PARTICLES
CHEMISTRY
ELEMENTS
INTESTINAL ABSORPTION
ION EXCHANGE
IONS
LEAD
MAMMALS
METALS
ORGANIC COMPOUNDS
PECTINS
POLYSACCHARIDES
RATS
RODENTS
SACCHARIDES
TRACE AMOUNTS
UPTAKE
VERTEBRATES