Scintigraphic portrayal of the syndrome of multiple endocrine neoplasia type-2B

Journal Article · Wed Jun 01 04:00:00 EDT 1988 · Clin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1097/00003072-198806000-00011· OSTI ID:7074240

Yobbagy, J J; Levatter, R; Sisson, J C; Shulkin, B L; Polley, T

The scintigraphic appearance of the neoplasms in multiple endocrine neoplasia type 2B (MEN-2B) and the interpretations of the image patterns are described. An 18-year-old male patient with the MEN-2B syndrome underwent TI-201 imaging that showed concentrations of TI-201 in the primary medullary thyroid carcinoma (MTC) tumor and in cervical lymph node metastases. After total thyroidectomy and lymph node dissection, the TI-201 image was normal. Catecholamine levels in the blood and urine were only borderline elevated. Yet, greater than normal concentrations of I-131 metaiodobenzylguanidine (I-131 MIBG) were present in both adrenal glands. Computed tomography of the abdomen showed normal adrenal glands. These results were consistent with the diagnosis of adrenal medullary hyperplasia, a precursor of pheochromocytoma. No operation was indicated to remove the adrenal glands. Imaging with TI-201 appears to be useful in identifying sites of MTC in patients with the MEN-2B syndrome. I-131 MIBG imaging, in conjunction with computed tomography of the adrenal glands and appropriate catecholamine measurements, should be performed in patients with the MEN-2B syndrome to determine the status of the adrenal medullae, which then may be classified as normal, hyperplastic, or tumorous with pheochromocytoma.

• Research Organization: Univ. of Michigan Medical Center, Ann Arbor (USA)
• OSTI ID: 7074240
• Journal Information: Clin. Nucl. Med.; (United States), Journal Name: Clin. Nucl. Med.; (United States) Vol. 13:6; ISSN CNMED
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
AMINES
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
CATECHOLAMINES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HEAVY NUCLEI
HYDROXY COMPOUNDS
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYMPH NODES
LYMPHATIC SYSTEM
MEDICINE
METASTASES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PHENOLS
POLYPHENOLS
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SURGERY
THALLIUM 201
THALLIUM ISOTOPES
THYROID
THYROIDECTOMY