Radiotracers binding to estrogen receptors: I: tissue distribution of 17 alpha-ethynylestradiol and moxestrol in normal and tumor-bearing rats

Journal Article · Thu Jul 01 04:00:00 EDT 1982 · J. Nucl. Med.; (United States)

OSTI ID:7071500

Feenstra, A; Nolten, G M; Vaalburg, W; Reiffers, S; Woldring, M G

Ethynylestradiol and moxestrol can be labeled with /sup 11/C by introducing this positron emitter in the 17 alpha-ethynyl group. To investigate their potential as radiotracers binding to estrogen receptors, researchers studied the tissue distribution of tritiated ethynylestradiol and moxestrol, with specific activities of 57 Ci/mmol and 77-90 Ci/mmol, respectively, in the adult female rat. At 30 min after injection, both compounds showed specific uptake in the uterus (% dose/g): 2.52 for ethynylestradiol and of 2.43 for moxestrol. A decrease of the specific activity to 6-9 Ci/mmol resulted in uterine uptakes of 1.60 and 2.10 respectively, for ethynylestradiol and moxestrol, at 30 min. In the female rat bearing DMBA-induced mammary tumors, specific uptake was also measured in the tumors, although the values were only 25-30% of the uterine uptake. Moxestrol showed a greater uptake selectivity in the tumors compared with ethynylestradiol. From this study researchers conclude that ethynylestradiol and moxestrol have good potential as tracers binding to mammary tumors that contain estrogen receptors.

• Research Organization: University Hospital, Groningen, The Netherlands
• OSTI ID: 7071500
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BINDING ENERGY
BODY
CARBON 11
CARBON ISOTOPES
DISEASES
DISTRIBUTION
ENERGY
ESTROGENS
EVEN-ODD NUCLEI
GLANDS
HORMONES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MAMMARY GLANDS
MEASURING METHODS
METABOLISM
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ORGANS
RADIOISOTOPES
RATS
RODENTS
STEROID HORMONES
TISSUE DISTRIBUTION
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES