Gallium 67 imaging in monitoring lymphoma response to treatment
The value of gallium 67 (Ga) imaging in monitoring lymphoma response to treatment was assessed in 25 patients with Ga-avid tumors and compared to body computed tomography (CT), chest radiographs, and palpation of tumor infiltrated peripheral lymph nodes. Ga imaging was negative in 95% (20/21) of the patients who were clinically considered to be in remission and in whom treatment was stopped. The disease did not recur during a follow-up of 12 to 26 months in 15 patients. Six patients developed recurrence of the disease 3 to 12 months after treatment was stopped. In all six patients Ga imaging became positive again at the time of the appearance of active disease. In the group of patients in remission, CT was negative in 57% (11/19), chest x-rays in 55% (6/11) and peripheral lymph nodes were palpated in none of the patients (13/13). In four patients that did not achieve remission after treatment, Ga scans were positive. Ga imaging appears useful in monitoring lymphoma response to treatment. This is probably because Ga imaging monitors tumor cell viability, whereas body CT and chest radiographs show the tumor mass, which may consist of fibrotic or necrotic tissue.
- Research Organization:
- Rambam Medical Center, Haifa (Israel)
- OSTI ID:
- 7069508
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 61:12
- Country of Publication:
- United States
- Language:
- English
Similar Records
Planning mantle radiation therapy in patients with Hodgkin disease: role of gallium-67 scintigraphy
Indications for total cutaneous electron beam radiation therapy of mycosis fungoides
Related Subjects
LYMPHOMAS
DIAGNOSIS
RADIOISOTOPE SCANNING
SENSITIVITY ANALYSIS
TUMOR CELLS
VIABILITY
BIOMEDICAL RADIOGRAPHY
COMPARATIVE EVALUATIONS
GALLIUM 67
LYMPH NODES
PATIENTS
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
IMMUNE SYSTEM DISEASES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LYMPHATIC SYSTEM
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
RADIOLOGY
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550602 - Medicine- External Radiation in Diagnostics- (1980-)