Thymic atrophy characteristic in transgenic mice that harbor pX genes of human T-cell leukemia virus type I

Journal Article · Sat Jul 01 04:00:00 EDT 1989 · Journal of Virology; (USA)

OSTI ID:7067579

Furuta, Yasuhide; Aizawa, Shinichi; Suda, Yoko; Ikawa, Yoji ^[1]; Kishimoto, Hidehiro; Asano, Yoshihiro; Tada, Tomio ^[2]; Hikikoshi, Atsuko; Yoshida, Mitsuaki; Seiki, Motoharu ^[3]

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1. Physical and Chemical Institute (RIKEN), Ibaraki (Japan)
2. Univ. of Tokyo (Japan)
3. Cancer Institute, Tokyo (Japan)

The human T-cell leukemia viruses (HTLV) are associated with T-cell malignancies in humans. The malignant transformation occurs after a long latency in some carriers, and its mechanism appears to be distinct from that of other classes of retroviruses which induce transformation through viral or cellular oncogenes. A widely postulated explanation is that the products of novel pX genes transactivate endogenous cellular genes which lead to tumor development in T cells. To directly examined the pathological effects of pX genes in vivo, the authors produced transgenic mice harboring the HTLV type I pX genes under several regulatory units: HTLV type I long terminal repeat, immunoglobulin enhancer-simian virus 40 promoter, and mouse mammary tumor virus long terminal repeat. Atrophy of the thymus was characteristic in these mice no matter which regulatory unit directed the expression of the genes.

• OSTI ID: 7067579
• Journal Information: Journal of Virology; (USA), Journal Name: Journal of Virology; (USA) Vol. 63:7; ISSN 0022-538X; ISSN JOVIA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ATROPHY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DNA
DNA HYBRIDIZATION
GENE REGULATION
GENE REPRESSORS
GENES
GENETIC MAPPING
GLOBULINS
HYBRIDIZATION
IMMUNOGLOBULINS
LEUKEMIA VIRUSES
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MAN
MAPPING
MATERIALS
MICE
MICROORGANISMS
NUCLEIC ACIDS
NUCLEOPROTEINS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
ORGANS
PARASITES
PATHOLOGICAL CHANGES
PRIMATES
PROTEINS
RECOMBINANT DNA
RODENTS
SOMATIC CELLS
THYMUS
VERTEBRATES
VIRUSES