Bleomycin-induced DNA repair by Saccharomyces cerevisiae ATP-dependent polydeoxyribonucleotide ligase
Journal Article
·
· Journal of Bacteriology; (USA)
OSTI ID:7067535
- Univ. of Rochester School of Medicine and Dentistry, NY (USA)
In contrast to ligase-deficient (cdc9) Saccharomyces cerevisiae, which did not rejoin bleomycin-induced DNA breaks, ligase-proficient (CDC9) yeast cells eliminated approximately 90% of DNA breaks within 90 to 120 min after treatment. Experimental conditions restricted enzymatic removal of the unusual 3{prime}-phosphoglycolate terminal in DNA cleaved by bleomycin and involved doses producing equivalent numbers of DNA breaks or doses producing equivalent killing.
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 7067535
- Journal Information:
- Journal of Bacteriology; (USA), Journal Name: Journal of Bacteriology; (USA) Vol. 170:10; ISSN JOBAA; ISSN 0021-9193
- Country of Publication:
- United States
- Language:
- English
Similar Records
cdc9 Ligase-defective mutants of Saccharomyces cerevisiae exhibit lowered resistance to lethal effects of bleomycin
Degradation of DNA and structure-activity relationship between bleomycins A sub 2 and B sub 2 in the absence of DNA repair
Ligase-deficient yeast cells exhibit defective DNA rejoining and enhanced gamma ray sensitivity
Journal Article
·
Wed Sep 01 00:00:00 EDT 1982
· J. Bacteriol.; (United States)
·
OSTI ID:5751422
Degradation of DNA and structure-activity relationship between bleomycins A sub 2 and B sub 2 in the absence of DNA repair
Journal Article
·
Mon Feb 05 23:00:00 EST 1990
· Biochemistry; (USA)
·
OSTI ID:6709383
Ligase-deficient yeast cells exhibit defective DNA rejoining and enhanced gamma ray sensitivity
Journal Article
·
Tue Jun 01 00:00:00 EDT 1982
· J. Bacteriol.; (United States)
·
OSTI ID:6578198
Related Subjects
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
ATP
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL FUNCTIONS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLEOMYCIN
DNA REPAIR
DRUGS
ENZYMES
EUMYCOTA
FUNCTIONS
FUNGI
KINETICS
LIGASES
MICROORGANISMS
MUTANTS
NUCLEOTIDES
ORGANIC COMPOUNDS
PLANTS
REACTION KINETICS
RECOVERY
REPAIR
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
YEASTS
59 BASIC BIOLOGICAL SCIENCES
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
ATP
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL FUNCTIONS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLEOMYCIN
DNA REPAIR
DRUGS
ENZYMES
EUMYCOTA
FUNCTIONS
FUNGI
KINETICS
LIGASES
MICROORGANISMS
MUTANTS
NUCLEOTIDES
ORGANIC COMPOUNDS
PLANTS
REACTION KINETICS
RECOVERY
REPAIR
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
YEASTS