Placental and lymphocyte markers of human exposure to polychlorinated biphenyls and polychlorinated dibenzofurans

Conference · Thu Sep 01 04:00:00 EDT 1988 · Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA)

OSTI ID:7067510

Lucier, G W; Wong, T; Sunahara, G I; Lundgren, K; Thompson, C ^[1]

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1. National Institute of Environmental Health Sciences, Research Triangle Park, NC (USA)

Human exposure to toxic halogenated aromatics has occurred through accidental contamination of the food and the environment. One of the most severe episodes occurred in 1979, when rice oil contaminated with polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) was consumed by approximately 2000 people in several counties of Taiwan. Total ingestion was estimated at 1-3 g PCBs and 0.5 mg PCDFs per individual. This unfortunate episode provided an opportunity to evaluate biochemical changes in a human population exposed to toxic halogenated aromatics. The objectives of their study were to evaluate placentas from exposed women for PCB and PCDF tissue concentrations, cytochrome P-450 isozymes, Ah receptor and epidermal growth factor (EGF) binding properties. Placentas were obtained approximately four years after the exposure had occurred. All women were non-smokers, were not taking any medications and had no recognized radiation or chemical exposure. The average age for both the exposed and non-exposed (women residing in the same counties) was 34 years. Placental homogenates and microsomes from exposed subjects showed marked elevation of aryl hydrocarbon hydroxylase (AHH) activities compared to control samples. Western blot analysis of placental microsomes prepared from exposed individuals revealed a protein which was immunochemically-related to rabbit lung cytochrome P-450 form 6, an isozyme induced by polycyclic aromatic hydrocarbons.

• OSTI ID: 7067510
• Report Number(s): CONF-8909236--
• Conference Information: Journal Name: Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA) Journal Volume: 28:2
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
540220 -- Environment
Terrestrial-- Chemicals Monitoring & Transport-- (1990-)
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
ASIA
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CEREALS
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE CELLS
CONTAMINATION
DISTRIBUTION
ENZYME ACTIVITY
ENZYME INDUCTION
ENZYMES
FETAL MEMBRANES
FOOD CHAINS
GENE REGULATION
GRASS
GROWTH FACTORS
HALOGENATED AROMATIC HYDROCARBONS
HYDROXYLASES
INGESTION
INTAKE
ISLANDS
LEUKOCYTES
LILIOPSIDA
LYMPHOCYTES
MAGNOLIOPHYTA
MAMMALS
MAN
MATERIALS
MEMBRANES
MICROSOMES
MITOGENS
MIXED-FUNCTION OXIDASES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANOIDS
OXIDOREDUCTASES
OXYGENASES
PLACENTA
PLANTS
POLLUTION
PRIMATES
PROTEINS
RIBOSOMES
RICE
SOMATIC CELLS
TAIWAN
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES