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Infratentorial glioblastoma: the role of neuraxis irradiation. [/sup 60/Co: X-rays]

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The patterns of clinical- and autopsy-documented tumor spread evaluated for 15 patients with biopsy-proven infratentorial (8 cerebellar, 2 brainstem, 5 intramedullary spinal cord) glioblastoma. No patient developed clinical nor autopsy evidence of subarachnoid dissemination, even though no patient had received craniospinal axis irradiation. Fully 14 of the 21 previously reported patients with subarachnoid dissemination from infratentorial glioblastoma had this diagnosis made only at autopsy. The overall poor prognosis at present (8% 3-year survival from the present series and recent literature) along wih the demonstrated pattern of local-reginal aggressiveness as the major form of initial spread and post-irradiation recurrence, suggest that routine craniospinal axis irradiation may not be indicated for most patients with infratentorial glioblastoma.
Research Organization:
Massachusetts General Hospital, Boston
OSTI ID:
7067234
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:6; ISSN IOBPD
Country of Publication:
United States
Language:
English

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