Protective effects of WR-2721 against radiation-induced injury of murine gut, testis, lung, and lung tumor nodules
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
WR-2721 (S-3-(3 aminopropylamino) ethylphosphorothioic acid) has been investigated for its ability to protect gut, lung, and testis, as well as fibrosarcoma (FSa) tumor nodules, in the lungs of mice from gamma-radiation injury. This compound greatly protected jejunum and testis epithelial cells. FSa micrometastases in the lung were protected in a lesser extent than jejunum and testis. Conversely, WR-2721 was not able to protect the lung against radiation-induced enhancement of tumor metastases formation generated by intravenously injected FSa cells.
- Research Organization:
- M.D. Anderson Hospital and Tumor Inst., Houston, TX
- OSTI ID:
- 7065981
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:3/4; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
GONADS
INJURIES
INTESTINES
IONIZING RADIATIONS
IRRADIATION
LUNGS
MALE GENITALS
MAMMALS
METASTASES
MICE
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
RODENTS
SARCOMAS
TESTES
THIOIC ACIDS
VERTEBRATES
WHOLE-BODY IRRADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
GONADS
INJURIES
INTESTINES
IONIZING RADIATIONS
IRRADIATION
LUNGS
MALE GENITALS
MAMMALS
METASTASES
MICE
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
RODENTS
SARCOMAS
TESTES
THIOIC ACIDS
VERTEBRATES
WHOLE-BODY IRRADIATION