The radioprotective effect of 5-thio-D-glucose on normal tissues in vivo. [/sup 60/Co; mice]

Journal Article · Mon Mar 01 04:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90690-3· OSTI ID:7065912

Schuman, V L; Levitt, S H; Song, C W

The radioprotective effect of 5-thio-D-glucose (5-TG, NSC 204984) on normal tissues of mice was investigated. The LD/sub 50/ of 5-TG in A/J mice injected intraperitoneally (i.p.) is 5.5 g/kg. Tha animals were injected i.p. with saline or 5-TG followed by whole-body irradiation or localized irradiation of the foot. Mice injected with 1.5 g/kg of 5-TG were protected from gastrointestional or bone marrow death following whole-body irradiation by a dose modification factor (DMF) of 1.1-1.3. The same dose of 5-TG protected mice from foot skin damage between days 0 and 40 post-irradiation by a DMF of 1.3, and from late foot deformity during days 60 and 90 post-irradiation by a DMF of 1.2. Foot skin reactions indicated that 5-TG provided maximal radioprotection up to 4 hours after an intraperitoneal injection. We have previously reported that 5-TG selectively kills and radiosensitizes hypoxic cells. Consequently, it may be possible to use this compound as an adjuvant to radiotherapy in order to kill or radiosensitize hypoxic cells and to radioprotect normal tissue.

• OSTI ID: 7065912
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:3/4; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CARBOHYDRATES
COBALT 60
COBALT ISOTOPES
DIGESTIVE SYSTEM
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
HEMATOPOIETIC SYSTEM
HEXOSES
IN VIVO
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LETHAL DOSES
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
MORTALITY
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RODENTS
SACCHARIDES
SKIN
SURVIVAL TIME
TISSUES
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES