The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, Minnesota. II. Regression relationships with concomitants

Journal Article · Mon Nov 30 23:00:00 EST 1992 · American Journal of Human Genetics; (United States)

OSTI ID:7063464

Reilly, S L; Sing, C F ^[1]; Ferrell, R E ^[2]; Kottke, B A ^[3]

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1. Univ. of Michigan, Ann Arbor (United States)
2. Univ. of Pittsburgh, PA (United States)
3. Mayo Clinic, Rochester, MN (United States)

The influence of the apolipoprotein E (Apo E) polymorphism and gender on the regression relationships between each of nine plasma lipid and apolipoprotein traits (total cholesterol; ln triglycerides; high-density-lipoprotein chloesterol; apolipoproteins AI, AII, B, and CII; ln CIII; and ln E) and four concomitants (age, weight, waist-to-hip ratio, and smoking) was studied in 507 unrelated individuals representative of the adult population of Rochester, MN. Analyses are presented separately for females and males. Each lipid and apolipoprotein trait exhibited at least one Apo E genotype-specific regression relationship with the concomitants investigated in this study. In most cases the heterogeneity of regression was associated with differences between the [var epsilon]32 and [var epsilon]33 genotype. This study documents that the influence of Apo E genotype on average levels of plasma lipids and apolipoproteins varies among subdivisions of the population defined by age, body size, and smoking status. 61 refs., 1 fig., 5 tabs.

• OSTI ID: 7063464
• Journal Information: American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 51:6; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
APOLIPOPROTEINS
BIOLOGICAL VARIABILITY
BODY
DEVELOPED COUNTRIES
DISTRIBUTION
FEMALES
GENETIC VARIABILITY
GENOTYPE
HUMAN POPULATIONS
LEVELS
LIPIDS
LIPOPROTEINS
MALES
MINNESOTA
NORTH AMERICA
ORGANIC COMPOUNDS
PLASMA
POPULATIONS
PROTEINS
SIZE
USA
WEIGHT