Radiosensitivity of skin fibroblasts from atomic bomb survivors with and without breast cancer

Journal Article · Sun Jul 01 04:00:00 EDT 1990 · Cancer Research; (USA)

OSTI ID:7062402

Ban, S; Setlow, R B; Bender, M A; Ezaki, H; Hiraoka, T; Yamane, M; Nishiki, M; Dohi, K; Awa, A A; Miller, R C ^[1]

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1. Radiation Effects Research Foundation, Hiroshima (Japan)

Fibroblasts were established in vitro from skin biopsies obtained from 55 women and 1 man with or without breast cancer and with or without exposure to radiation from the atomic bomb explosion in Hiroshima. The radiosensitivity of these cells was evaluated by clonogenic assays after exposure to X-rays or to fission neutrons from a {sup 252}Cf source. Data were fitted to a multitarget model, S/S0 = A (1 - (1 - ekD)N), for both X-ray and neutron dose-survival curves. A single hit model, S/S0 = AekD, fits the neutron dose-survival responses as well. There were no differences in the means or variances of radiosensitivity between exposed and nonexposed groups or between patients with or without breast cancer. Hence, although the sample is not large, it provides no support for the hypothesis that atomic bomb radiation preferentially induces breast cancer in women whose cells in vitro are sensitive to cell killing by radiation.

• OSTI ID: 7062402
• Journal Information: Cancer Research; (USA), Journal Name: Cancer Research; (USA) Vol. 50:13; ISSN 0008-5472; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
A-BOMB SURVIVORS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ASIA
BARYONS
BIOPSY
BODY
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CELL KILLING
CONNECTIVE TISSUE CELLS
DIAGNOSTIC TECHNIQUES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EVEN-EVEN NUCLEI
FALLOUT
FERMIONS
FIBROBLASTS
FISSION NEUTRONS
GLANDS
HADRONS
HEAVY NUCLEI
HIROSHIMA
HUMAN POPULATIONS
IONIZING RADIATIONS
ISOTOPES
JAPAN
MAMMARY GLANDS
MATHEMATICAL MODELS
NEOPLASMS
NEUTRONS
NUCLEI
NUCLEONS
ORGANS
POPULATIONS
RADIATION DOSES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY
SKIN
SOMATIC CELLS
SURVIVAL TIME
X RADIATION
YEARS LIVING RADIOISOTOPES