Localization of the gene (OGDH) coding for the E1k component of the [alpha]-ketoglutarate dehydrogenase complex to chromosome 7p13-p11. 2
- Cornell Univ. Medical College, New York, NY (United States)
[alpha]-Ketoglutarate dehydrogenase (E1k), also designated oxoglutarate dehydrogenase (OGDH; EC 1.2.4.2), is a component of the enzyme complex that catalyzes the conversion of [alpha]-ketogluterate to succinyl coenzyme A, a critical step in the Krebs tricarboxylic acid cycle. Deficiencies in the activity of this enzyme complex have been observed in brain and peripheral cells of patients with Alzheimer's disease. This finding led the authors to localize the genes for the polypeptides that compose the [alpha]-ketoglutarate dehydrogenase complex (KDGHC). The E1k locus was mapped to chromosome 7p13-p11.2 using a pair of human-rodent somatic cell hybrid panels. A second related sequence, possibly a pseudogene, was identified and mapped to chromosome 10. 16 refs., 1 fig.
- OSTI ID:
- 7062129
- Journal Information:
- Genomics; (United States), Journal Name: Genomics; (United States) Vol. 20:2; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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